Principal Investigator: Kevin Hiom
Pat McPherson Chair of Cancer Biology
HIOM LAB
Medical Research Institute
Jacqui Wood Cancer Centre
James Arrott Drive
Ninewells Medical School & Hospital
University of Dundee. DD1 9SY
email: k.hiom@dundee.ac.uk
ph: +44 (0)1382 383360
Medical Research Institute & Dundee Cancer Centre
Genome Instability & Cancer
Cancer cells exhibit profound genomic instability resulting in the accumulation of mutations and DNA breaks as well as gross chromosomal rearrangements and aberrations. Loss of genome stability is commonly associated with defects in proteins which signal the presence of DNA lesions and participate in their repair as part of the DNA Damage Response. Inherited defects in DDR factors are responsible for a broad range of human diseases and cancer predisposing conditions, including Fanconi’s anaemia, Ataxia telangiectasia, Seckel syndrome and early onset breast and ovarian cancer.
As well as being a driving force towards cancer, defects in the DDR sensitise cancer cells to agents that damage DNA and therefore can be exploited in therapy.
Recruitment
The MRI at Dundee is looking for junior group leaders in cancer research, who have the potential to attract a research fellowship, for its tenure-track program. Current research strengths in the MRI include genome stability, signalling, epithelial biology and stress responses. In particular researchers with interest and expertise in cancer cell biology are encouraged to apply.
Funded By:
Ninewells
Cancer
Campaign
Manuscript accepted by MCB on the role of BRCA1 in the Fanconi Anemia pathway